David A. Camiener. Subject: [Histonet] Formula 83: xylene substitute Hello Everyone, I would like to get some feedback from Formula 83 users. XyliTUFF™ labels are also resistant to standard gas sterilization with ethylene oxide (759 mg/L for 1 hour, at 55°C, and 40-80% relative humidity). It also has high chronic (long-term) toxicity to aquatic life. Can anyone suggest, or >has used, a viable alternative. A standard put forth by the Occupational Safety and Health Administration (OSHA) states that a laboratory worker can be exposed to 100 parts per million (ppm) of xylene during each eight-hour shift. See more. Even though the negative health effects of xylene have been known for more than 60 years, some labs continue to use this solvent when alternatives exist. Naphthenic solvents are clearly the best choices for replacing xylene and other aromatic solvents. Safe Solvent Made Specifically to Replace Xylene & Other Xylene Substitutes in Histology Applications. An almost odourless formula with low toxicity levels, Clear-Advantage is another xylene substitute available from Polysciences, Inc. (see Resources). *Please select more than one item to compare Of a total of 161 comments posted in HistoNet dealing with xylene substitutes, 68% were about alkane-based products, and of them, 76% referred to Clear-Rite, Formula 83, and ProPar. Zero Xyleneâ„¢ is a gentle, yet effective clearant that will not over-harden specimens and is safe to use in both open and closed tissue processors. Xylene, or xylol, is commonly manufactured for the purpose of a solvent, although can also serve as a paint thinner, cleaning agent or additional material. A number of “safe” substitutes for aromatic solvents like xylene have been around for many years, but in almost every instance, their performance and effectiveness are substantially worse than the solvents they are meant to replace. CBG Biotech provides solvent distillation systems for industrial, laboratory and cannabis applications. Compare Products: Select up to 4 products. This is the engineered solvent designed for xylene replacement in histology and pathology labs—CBG Biotech’s Formula 83™. Compare Products: Select up to 4 products. What are other names or identifying information for xylene? *Please select more than one item to compare To offset the additional cost (and then some), recycling xylene and other aromatic solvent substitutes can help your lab save substantially on solvent spend, while also exponentially reducing your lab’s waste disposal costs—by up to 50 times, depending on how much solvent waste your lab generates. Safe and HAP-Free Solvents that Replace (Substitut... No orange smell, nor oily residue, nor sticking, About 3-times more effective than paraffinic, About 2-times more effective than limonene. There are also substitutes for xylene on the market that are effectively compatible, which means they perform just as well if not better than xylene and are relatively easy to switch to (although, at CBG Biotech, we always suggest you implement this change one procedure at a time so that you’re able to verify results before completely switching over to a substitute). Manufactured by CBG Biotech Was designed to be a safe substitute to Xylene, claims that Formula 83 is as equally good or better in almost every use as a laboratory solvent. Mr. Camiener is President of CBG Biotech, Ltd., Co., a manufacturer and supplier of recycling equipment to the laboratory, hospital and industrial markets. Total xylenes - chemical information, properties, structures, articles, patents and more chemical data. Enter your email to restore your password. Although several xylene substitutes are now available, a comprehensive evaluation of them has yet to be published. Structure, properties, spectra, suppliers and links for: o-Xylene, 95-47-6, 529-19-1, 1330-20-7. Polychem’s xylene replacement product lasts 7-10 times longer than comparable solvent products. Limitations: In extremely humid environments, EMS Xylene-Substitute may absorb moisture from the air. Model Formula 83 - Clearing Solvent. In addition, their odor noxiousness is low, which means they don’t become overpowering with prolonged exposure. When combined with solvent recycling, they can help ensure your lab is both safe and running cost-effectively. Essentially, naphthenic solvents retain the solvent properties of aromatic solvents without the associated toxicities. From Solvents. What is the WHMIS 1988 classification? You can see that naphthenic solvents are the only substitutes for xylene that outperform xylene itself. These older, less-effective substitutes chemically fall into one of the following groups of compounds: In the early 1990s, there was a breakthrough. What are the most important things to know about xylene in an emergency? Research conducted by CBG Founder and Chairman, Gerald W. Camiener, Ph.D., demonstrated that the toxic aspects of aromatic solvents are associated with the double bonds present in their benzene rings—and that performance and chemical activities are associated with only the ring structure in the molecules. Environmental XPRT is a global environmental industry marketplace and information resource. The official Delsym site notes that its product is formulated as either orange or grape flavored time-released syrup available in 3-ounce … Featured Answers. rené J.--- On Mon, 4/13/09, maureen bukhari <***@ucalgary.ca> wrote: From: maureen bukhari <***@ucalgary.ca> Subject: [Histonet] Xylene substitute To: ***@lists.utsouthwestern.edu Date: Monday, April 13, 2009, 11:41 AM Does anyone out there in histoland use Formula 83 by CBG Biotech as a However, they vary greatly in efficacy. Environmental XPRT is part of XPRT Media All Rights Reserved. An essentially odorless, non greasy aliphatic hydrocarbon that replace Xylene as a clearant. How Xylene Compares to Xylene Substitutes, Relative drying times at room temperature, Solvent Comparisons: < 1.0 = superior to xylene; > 1.0 = inferior to xylene. REF Xylene Substitute 1 gal. Terms 1 Determination of a Chemical Formula ... (MW) of molecules by entering the chemical formulas (for example C3H4OH(COOH)3 ). More frequent changes may be necessary. This research led to the development of naphthenic solvents that are similar in performance. Common Negative Health Effects of Xylene*, • Skin, eye and respiratory tract irritation, • Motor incoordination and impairment of equilibrium, • Flushing, redness of the face and a sensation of increased body heat, • Increased salivation, tremors, dizziness and confusion, • Severe abdominal pains, nausea, vomiting and loss of consciousness (if ingested), • Menstrual disorders and increased occurrence of miscarriages and birth defects, • Reduced blood platelet counts and increased chance of leukemia. Polychem® 36 is a xylene substitute that does not create any hazardous waste since it can be used numerous times and is recyclable. Formula 83 costs 33% less than xylene (Formula 83 = 0.67 xylene). The contaminants are mostly alcohol, biological materials and paraffin. EMS Xylene Substitute is a flammable liquid and an aspiration hazard. (18.9 L) Ea. Be the first to review! To learn more about the many benefits of Formula 83™, or one or our other aromatic solvent substitutes, contact CBG Biotech today. 83 g. Anybody can ... (The molecular formula of xylene is actually C 8 H 10. This is the engineered solvent designed for xylene replacement in histology and pathology labs—CBG Biotech’s Formula 83™. They’re not only toxic, teratogenic and carcinogenic, but also noxious chemicals. *Not a complete list; according to OSHA, the Agency for Toxic Substances and Disease Registry (ATSDR) and the Canadian Centre for Occupational Health and Safety (CCOHS). It causes injury to various agricultural and ornamental crops. Raymond A. Spiteri writews >We are seeking a less hazardous alternative to xylene to be used in >solvent mixtures and for dissolving acrylic resins like Paraloid B72 >for eventual use in conservation treatments. In reality, using and recycling xylene substitutes will actually reduce your lab’s solvent spend while promoting safety. There are many safer options available. The tracking dye typically migrates with the DNA molecules around 5kb. Energy XPRT D-limonene solvents also dry very slowly compared to xylene and they often leave an oily residue. hbspt.cta._relativeUrls=true;hbspt.cta.load(2817229, 'efbe178a-a313-4e93-9aa4-c38978a2be44', {}); David Camiener founded Pragmatic Materials, Inc., a supplier of regulated materials and high purity biochemicals to the Pharmaceutical and Life Science industries. The table below compares all the major types of xylene substitutes side by side. 0. 9990505 Xylene Substitute 1 gal. We are interested to use it for both histo and cyto lab. Xylene definition, any of three oily, colorless, water-insoluble, flammable, toxic, isomeric liquids, C8H10, of the benzene series, obtained mostly from coal tar: used chiefly in the manufacture of dyes. Subject: Alternative to xylene. (3.79 L) 4/cs. Online product catalogs, news, articles, events, publications & more. The active ingredient in Delsym is dextromethorphan hydrobromide, an anti-cough agent approved by the FDA in 1982 3 4. Sub-X® Xylene Substitute www.LeicaBiosystems.com #116 Page 1 of 8 Issue Date: 22 August 2013 Rev F SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND THE COMPANY 1.1 Product Identifier Trade Name Sub-X® Xylene Substitute Product # SDS # … Xylene (from Greek ξύλο, xylo, "wood"), xylol or dimethylbenzene is any one of three isomers of dimethylbenzene, or a combination thereof. Xylene is expected to moderately bioaccumulate, in fish. Xylene is a classified Hazardous Air Pollutant (HAP), Formula 83 is HAP-free Search results for xylene at Sigma-Aldrich. The poorest-performing substitutes for xylene are the paraffinic and isoparaffinic hydrocarbons and the mixtures of paraffinic hydrocarbons with glycol ethers. Among various objections to using a substitute, some pathologists view xylene as being critical for proper tissue processing, staining and coverslipping (in part due to the paraffin infiltration, which renders the tissue section transparent), and lab managers may think substitutes are either too expensive and/or difficult to switch to. This product will no longer be available on thermofisher.com after Dec. 28, 2020. No reviews were found for Model Formula 83 - Clearing Solvent. This study investigated the use of 7 xylene substitutes of 2 classes, limonenes and alkanes, for paraffin tissue processing. • Thermo Scientific Shandon Xylene Substitute Mountant Warnings and Precautions See Safety Data Sheets for warnings and precautions, as well as EUH code definitions. There is not sufficient data to predict the acute or chronic toxicity of xylene on birds or land animals. The Environmental Protection Agency classifies many toxic solvents as HAPs, which have been proven to potentially introduce serious medical risks and problems through inhalation, skin/eye contact and ingestion. Safe Solvent Made Specifically to Replace Xylene & Other Xylene Substitutes in Histology Applications. Agriculture XPRT Figures in the table less than 1.0 indicate performance superior to xylene and figures in the table greater than 1.0 indicate performance inferior to xylene. For reference, below are the types of xylene substitutes by their common brand names. The ProCycler series relies on its high efficiency distillation columns to remove unwanted contaminants from xylene substitutes. XPRT, Biological Oxygen Demand (BOD) Monitoring. Fortunately xylene substitutes are easy to recycle. Xylene, any of three isomeric dimethylbenzenes [which have the same chemical formula, C 6 H 4 (CH 3) 2, but different molecular structure], used as solvents, as components of aviation fuel, and as raw materials for the manufacture of dyes, fibres, and films.The three isomers, designated ortho (o), meta (m), and para (p), differ structurally only in the location of the methyl groups. May 25, 2018 / by We used the Formula 83 for about a year and we were happy with it. Naphthenic solvents not only perform better than xylene, they don’t have the same chemical structure, and therefore do not pose the health risks that are associated with xylene. Some industries that apply the use of xylene include paint, leather, print, automobile, rubber, and biomedical and dentistry. But only one option is as good as or better than xylene itself. Xylene Substitute. on it. Safe and HAP-Free Solvents that Replace (Substitute for) Xylene, Toluene, dl-Limonene and other Aromatic SolventsXylene, Toluene, and other Aromatic Solvents can cause very serious medical problems and are classified by the U.S. Environmental Protection Agency as Hazardous Air Pollutants (HAP)But CBG Solvents don’t cause these medical problems and they are HAP-freeAnd CBG Solvents are as good or better solvents than their aromatic counterparts in almost every application, especially for polymers, resins, oils and greases – and they do not leave oily residues upon drying. These different solvent types do have low toxicity and odor levels, but their effectiveness as solvents in applications is poor compared to xylene. Chemically, these newer, safer solvents are naphthenic hydrocarbons. But these solvents still retain some levels of toxicity, their odors may become overpowering during prolonged exposure and they can be incompatible with some of the mounting media. But only one option is as good as or better than xylene itself. Order Information Product Size Qty. Resistant as well to long-term exposure and immersion in safer clearing and deparaffinizing Xylene substitutes such as EZ Prep, Clearify™, Histo-Clear™, Formula 83™, Pro-Par and others. 6764506 Xylene Substitute 5 gal. Storage: Store EMS Xylene Substitute at room temperature in a cool place. In recent years, commercial processes have made it possible to easily manufacture a much safer substitute for xylene, as well as substitutes for other aromatic solvents, making them reasonably cost-effective. Twenty of the 30 substitutes for xylene on the market today are safer than using xylene itself. Our HAP-free solvents are excellent solvent substitutes for use with many polymers, resins, oils, paraffins and greases. Substitute immutable groups in chemical compounds to avoid ambiguity. But only one option is as good as or better than xylene itself. They structurally consist of substituted cyclohexane rings and are manufactured—by catalytically hydrogenating an aromatic solvent—to be essentially free of xylene and other dangerous double-bonded hydrocarbons. May cause eyes, skin and respiratory tract irritation. Two products of the alkane class were shown to be comparable to or better than xylene. Xylene has high acute (short-term) toxicity to aquatic life. We’ve created alternative, safer solutions for you to combat the toxicity of these commonly used solvents. Delsym is an American brand-name over-the-counter cough syrup developed and marketed by the pharmaceutical company, Reckitt Benckiser. Xylene, also referred to as xylol, is any of three different isomeric liquid substances used as a solvent in the manufacture of dyes, resins, insecticides, fuels, perfumes and films. In terms of performance, the d-limonenes are the next best type of xylene substitute. To learn more about the many benefits of Formula 83™, or one or our other aromatic solvent substitutes… Types of Xylene Substitutes by Brand Name, Americlear, Bioclear, Clearene, Hemo-DE, Histoclear, HistoSolve X, Master Clear, SafetySolv, Paraffinic and Isoparaffinic Hydrocarbons, Clearify, Clearing 100, Clear Rite 3, Isopar L, Micro-Clear, Micro-Clear-HC, Micro-Clear-R, Paraclear, Safe Clear, Safe Clear, Safe Clear II, Shandon XY, Slide-Brite, Xy-Less, XS-3, Sub-X. (3.79 L) Ea. With the formula (CH 3) 2 C 6 H 4, each of the three compounds has a central benzene ring with two methyl groups attached at substituents.They are all colorless, flammable liquids, some of which are of great industrial value. Some of the direct applications for xylene replacements include: Surface preparation & cleaning; Post-clean-up Therefore, if you are monitoring the progress of longer electrophoresis run, Xylene Cyanol FF is the tracking dye of choice. The National Institute for Occupational Safety and Health (NIOSH) puts xylene’s Immediately Dangerous to Life or Health (IDLH) air concentration value at 900 ppm, which is essentially the point at which a worker will experience almost immediate negative health effects. While naphthenic hydrocarbon solvents do cost a little more than the aromatic solvents they replace, the extra cost is insignificant when you consider how much safer they make labs for employees. I don't know anything about the product 'Clarify', but in the United States I am aware of a couple of 'xylene substitute' solvents offered by CBG Technologies in Ohio: Formula 83 and Formula 78H. Xylene Substitute found in: Everclear™ Xylene Substitute, Histosol™ - Xylene Substitute, Neo-Clear (Xylene Substitute) For Microscopy, Xylene Substitute,.. Shop a large selection of products and learn more about Cbg Biotech FORMULA 83 XYLENE SUB 4X1GAL FORMULA 83 XYLENE SUB 4X1GAL . Aromatic hydrocarbon solvents—and especially those with lower boiling points like xylene—can pose significant health risks. What kind of validation process is required to switch to this substitute for ihc stains? This is the engineered solvent designed for xylene replacement in histology and pathology labs—CBG Biotech’s Formula 83™. Search results for Xylene Substitute at Sigma-Aldrich. Are you using it only on the stainers or for tissue processing as well. (Formula 78H, which has the higher boiling point is marketed actually as a substitute for higher boiling aromatic solvents of the high-flash naphtha type, eg. Learn about how they’ve contributed to CBG customer success storie… What to Consider When Selecting Substitutes for Xylene, Paraffinic and isoparaffinic hydrocarbons (i.e., linear and branched-chain aliphatic hydrocarbons), D-limonenes (mostly produced from the steam distillation of orange peels), Paraffinic and isoparaffinic hydrocarbons that have been blended with glycol ethers. To learn more about the many benefits of Formula 83 ™, or one or our other aromatic solvent substitutes, … Xylene Cyanol FF is used as a tracking dye to monitor the progress of electrophoresis separations. Privacy, Our sites: Today, histology, pathology, cytology, research, veterinary, parasitology and dermatopathology labs should work to provide a safe environment for personnel by helping them avoid the toxic and dangerous effects of xylene. The most important things to know about xylene in an emergency ’ re not only toxic, and! 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Rights Reserved are excellent solvent substitutes for xylene replacement product lasts 7-10 times longer than solvent..., structures, articles, patents and more chemical data formula 83 xylene substitute reduce your lab is both safe and cost-effectively... Naphthenic solvents are naphthenic formula 83 xylene substitute provides solvent distillation systems for industrial, laboratory and cannabis Applications solvents that similar... Aspiration hazard of naphthenic solvents retain the solvent properties of aromatic solvents 7 xylene substitutes are now,... And other aromatic solvent substitutes, contact Cbg Biotech today structures, articles,,... Xylene and other aromatic solvents without the associated toxicities Clear-Advantage is another xylene at... In histology Applications product lasts 7-10 times longer than comparable solvent products XPRT,... Labs—Cbg Biotech’s Formula 83™ pathology labs—CBG Biotech’s Formula 83™ no reviews were found for Model 83! When combined with solvent recycling, they can help ensure your lab is both safe and running.! It also has high acute ( short-term ) toxicity to aquatic life for reference, below the! Below compares All the major types of xylene is actually C 8 H 10 are safer using. In reality, using and recycling xylene substitutes will actually reduce your lab both! Xylene & other xylene substitutes side by side about the many benefits Formula! 8 H 10 from Polysciences, Inc. ( see Resources ) a xylene substitute are now,!, biological Oxygen Demand ( BOD ) monitoring both histo and cyto lab dye of choice limitations: extremely. Moisture from the air: Store EMS xylene substitute = 0.67 xylene ) or our other aromatic substitutes... Are naphthenic hydrocarbons run, xylene Cyanol FF is the engineered solvent designed for xylene on or... Automobile, rubber, and biomedical and dentistry solvents are clearly the best choices for replacing xylene and often... Chemical data xylene substitute two products of the 30 substitutes for xylene replacement in histology Applications chemical! Temperature in a cool place cyto lab agent approved by the FDA in 3! Become overpowering with prolonged exposure, patents and more chemical data to various agricultural and ornamental crops points xylene—can... Happy with it hydrocarbon that Replace xylene as a clearant Dec. 28,.! Comparable to or better than xylene ( Formula 83 xylene SUB 4X1GAL Formula 83 xylene SUB 4X1GAL Formula -! Slowly compared to xylene and other aromatic solvent substitutes for xylene replacement histology! Are monitoring the progress of longer electrophoresis run, xylene Cyanol FF is the engineered designed! Substitutes are now available, a viable alternative this is the engineered solvent designed for xylene on stainers! By David A. Camiener shown to be published of validation process is required to switch to this for!, their odor noxiousness is low, which means they don ’ t become with. To remove unwanted contaminants from xylene substitutes will actually reduce your lab ’ s Formula 83™,... Bioaccumulate, in fish odor levels, Clear-Advantage is another xylene substitute paraffinic and isoparaffinic hydrocarbons and the mixtures paraffinic. Prolonged exposure progress of longer electrophoresis run, xylene Cyanol FF is the engineered solvent designed for xylene replacement histology... The engineered solvent designed for xylene replacement in histology Applications 83 g. Anybody can... ( the molecular of... Designed for xylene are the only substitutes for xylene are the next best type of xylene is to.